Tablets of mosapride citrate and preparation method thereof

一种枸橼酸莫沙必利的片剂及其制备方法

Abstract

本发明属于医药领域,具体涉及一种含有枸橼酸莫沙必利的片剂及其制备方法。由于枸橼酸莫沙必利几乎不溶于水,按照普通方法制备的枸橼酸莫沙必利片均存在溶出缓慢,体外和体内生物利用度较低的缺陷。为了提高枸橼酸莫沙必利的溶出度和生物利用度,本发明提供了一种含有枸橼酸莫沙必利的分散片及其制备方法。本发明制备的枸橼酸莫沙必利分散片溶出速度快,溶出差异小,5min累积溶出量接近100%,几乎全部溶出。
The invention belongs to the field of medicaments and in particular relates to tablets containing mosapride citrate and a preparation method thereof. Because the mosapride citrate is almost insoluble, defects of slow dissolution and low in-vitro and in-vivo bioavailability are present in the mosapride citrate tablets prepared by the common method. In order to improve the dissolution and bioavailability of the mosapride citrate, the invention provides dispersible tablets containing the mosapride citrate and a preparation method thereof. The prepared mosapride citrate dispersible tablets have high dissolution speed and low dissolution difference. The accumulated dissolution in five minutes is close to 100 percent, and the dispersible tablets are almost dissolved completely.

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Cited By (6)

    Publication numberPublication dateAssigneeTitle
    CN-102600091-AJuly 25, 2012威海迪素制药有限公司, 迪沙药业集团山东迪沙药业有限公司, 迪沙药业集团有限公司Itopride hydrochloride dispersible tablet composition
    CN-104188927-ADecember 10, 2014鲁南制药集团股份有限公司Mosapride citrate tablet and preparation method thereof
    CN-104546686-AApril 29, 2015南京工业大学Mosapride citrate co-grinded product, preparation method thereof and medicine composition containing mosapride citrate co-grinded product
    CN-104546686-BDecember 01, 2017南京百思福医药科技有限公司一种枸橼酸莫沙必利共研磨物及其制备方法和含其药物组合物
    CN-104622826-AMay 20, 2015孙巧玲一种枸橼酸莫沙必利片剂及其制备方法
    CN-105560249-AMay 11, 2016成都康弘药业集团股份有限公司一种含有枸橼酸莫沙必利的药物组合物