analgesia (Total 715 Patents Found)

A improved method of treating pain is disclosed. The method includes administering to a subject an N-type voltage-sensitive calcium channel blocking omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conop...
Dispositivo de administración transdérmica de buprenorfina que comprende una capa de matriz polimérica quecontiene buprenorfina o una sal de la misma farmacéuticamente aceptable, para su uso en el tratamiento deldolor en un paciente durante un intervalo de dosificación de por lo menos 5 días, en donde el disposit...
A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA bind...
A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of bup...
The invention relates to a method for monitoring a condition of a patient under anesthesia or sedation, whereupon one, two, three or more signals are acquired, and the signal(s) represent(s) cardiovascular and/or combined electrical biopotential on skull activity of the patient. From said signal or signals are derived ...
A method of producing analgesia in a mammal is provided by rotational (alternating) intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist, such as a μ-, δ-, or κ-opioid receptor agonist for a first period of time, followed by intrathecal administration ...
The present invention relates to systems and methods for providing a short-acting analgesic agent in the management of pain during labor, wherein the system enables efficient, real-time prediction of contractions for the coordinated administration of analgesia such that the peak effectiveness of the analgesic coincides...
A method for evaluating drug sensitivity, characterized by correlating a combination of gene polymorphisms of at least two genes independently selected from the group consisting of a GIRK channel gene, a mu-opioid receptor gene, a voltage-dependent calcium channel gene, an adrenaline receptor gene and a gene for a prot...
Abstract of the Disclosure A patient-controlled analgesia (PCA) apparatus capable of additional administration simultaneously with continuous injection is provided, in which a drug solution can be additionally administered via a release valve while being injected continuously in a slight amount via a flow rate c...
A small, handheld, microelectric, direct current generator with a low frequency modality is applied directly to a wound site through a composite wound covering or dressing. An electric potential difference is established between an anode and cathode of the composite wound dressing. Wound healing is facilitated by the b...
A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W—[X 1 X 2 X 3 . . . X 43 X 44 X 45 ] n ValAlaX 48 GlyLeu[X 51 X 5...
1,9-Dihydroxyoctahydrobenzo[c]quinolines (I), 1-hydroxyhexahydrobenzo[c]quinoline-9 (8H)-ones (II), and 1-hydroxy-tetrahydrobenzo[c]quinolines (IV) useful as CNS agents, especially as analgesics and tranquilizers, as hypotensives, as agents for the treatment of glaucoma and as diuretics; intermediates therefor (III) an...
本实用新型公开了一种具有抗感染功能的硬膜外-皮下埋藏式镇痛泵,包括底座(2),在所述底座(2)内设有空腔,所述空腔由大圆形空腔(21)和小圆形空腔(22)组成,大圆形空腔(21)位于小圆形空腔(22)的正上方;硅胶盖组件(4)的下端与大圆形空腔(21)...
The use of buprenorphine in the preparation of a medicament for a method of effectively treating pain in humans is achieved by administering buprenorphine in a manner indicative of first order pharmacokinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to abo...
电子输液泵的PCA输液参数自动调节方法包括以下步骤:步骤S1:在预设计时周期内通过PCA组件获取PCA激活信号的次数;步骤S2:判断在预设计时周期内的PCA激活信号的次数小于或等于次数下限阈值,还是大于次数下限阈值且小于次数上限阈值,...
A preparation suitable for sustained and extended corneal analgesia and for repeated administration consisting of ultralow nontoxic subanaesthetic concentrations of local anesthetic agents. A method for corneal analgesia has a fast onset of pain relief and extended duration of the corneal analgesia for several months w...
The invention relates to methods for inducing analgesia (or even anesthesia) and for prevention or amelioration of damage caused by injury of tissues in general, but especially neural, for the central nervous system being the most vulnerable of all tissues, by the systemic administration of a therapeutically effective ...
The invention relates to a method for monitoring a condition of a patient under anesthesia or sedation, whereupon one, two, three or more signals are acquired, and the signal(s) represent(s) cardiovascular and/or combined electrical biopotential on skull activity of the patient. From said signal or signals are derived ...
A method of producing analgesia in a mammal is provided by rotational (alternating) intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist, such as a ν-, δ- or λ-opioid receptor agonist for a first period of time, followed by intrathecal administration t...
The invention relates to methods for inducing analgesia (or even anesthesia) and for prevention or amelioration of damage caused by ischemic or traumatic injury of tissues in general, but especially neural, for the central nervous system being the most vulnerable of all tissues, by the systemic administration of a ther...
Inhalant anesthetics are developed with a number of properties including rapid onset and recovery, controllability, and, ideally, a broad safety profile. The efficacy of these agents is measured by their ability to create anesthesia within the framework of the other desirable properties. The instant invention focuses o...
The invention relates to a drug delivery device for providing local analgesia, local anesthesia or nerve blockade at a site in a human or animal in need thereof, the device comprising a fibrillar collagen matrix; and at least one drug substance selected from the group consisting of amino amide anesthetics, amino ester ...
Described is a method and system which includes a first set of digital data generated by amplifying and digitizing brain waves of a patient before and after administration of initial doses of interventional agents to the patient and a second set of digital data generated by amplifying and digitizing brain waves of the ...
A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of bup...
A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of bup...